Chandrasekhar, Sosale and Karri, Phaneendrasai (2007) Erlenmeyer azlactone synthesis with aliphatic aldehydes under solvent-free microwave conditions. In: Tetrahedron Letters, 48 (5). pp. 785-786.
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2-Phenyl-5(4H)-oxazolone (azlactone) reacts with aliphatic aldehydes upon adsorption on neutral alumina and irradiation with microwaves (<2 min). The corresponding condensation products are obtained in good yields (62–78%), indicating the satisfactory resolution of a long-standing problem plaguing the classical Erlenmeyer synthesis (poor results with aliphatic aldehydes). Plausible mechanistic reasons for the success of the procedure are discussed.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||27 Mar 2007|
|Last Modified:||19 Sep 2010 04:36|
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