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Erlenmeyer azlactone synthesis with aliphatic aldehydes under solvent-free microwave conditions

Chandrasekhar, Sosale and Karri, Phaneendrasai (2007) Erlenmeyer azlactone synthesis with aliphatic aldehydes under solvent-free microwave conditions. In: Tetrahedron Letters, 48 (5). pp. 785-786.

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Abstract

2-Phenyl-5(4H)-oxazolone (azlactone) reacts with aliphatic aldehydes upon adsorption on neutral alumina and irradiation with microwaves (<2 min). The corresponding condensation products are obtained in good yields (62–78%), indicating the satisfactory resolution of a long-standing problem plaguing the classical Erlenmeyer synthesis (poor results with aliphatic aldehydes). Plausible mechanistic reasons for the success of the procedure are discussed.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 27 Mar 2007
Last Modified: 19 Sep 2010 04:36
URI: http://eprints.iisc.ernet.in/id/eprint/10234

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