Stereoselective syntheses of \gamma-alkyl (aryl)-$\alpha$, $_\beta$ -dihydroxy-\gamma-butyrolactones and naturally occurring lipid guggultetrol

Prasad, Kavirayani R and Chandrakumar, Appayee (2007) Stereoselective syntheses of \gamma-alkyl (aryl)-$\alpha$, $_\beta$ -dihydroxy-\gamma-butyrolactones and naturally occurring lipid guggultetrol. In: Tetrahedron, 63 (8). pp. 1798-1805.

PDF Stereoselective_syntheses_of.pdf Restricted to Registered users only Download (309Kb) | Request a copy

Abstract

\gamma-Oxo-butyramides derived from tartaric acid serve as excellent precursors for the synthesis of \gamma-alkyl (aryl)-$\alpha$, $_\beta$-dihydroxy-\gamma- butyrolactones and for the synthesis of tetrols containing three contiguous stereogenic centres. The methodology presented here is general for the synthesis of \gamma-alkyl (aryl)-$\alpha$, $_\beta$-dihydroxy-\gamma-butyrolactones.Utility of the chiral building block was demonstrated by the synthesis of naturally occurring lipid guggultetrol.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to Elsevier.
Keywords:	g-Butyrolactone;Stereoselective reduction;L-(+)-Tartaric acid;Guggultetrol
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	27 Mar 2007
Last Modified:	19 Sep 2010 04:36
URI:	http://eprints.iisc.ernet.in/id/eprint/10240

Actions (login required)

View Item