Prasad, Kavirayani R and Chandrakumar, Appayee (2007) Stereoselective syntheses of \gamma-alkyl (aryl)-$\alpha$, $_\beta$ -dihydroxy-\gamma-butyrolactones and naturally occurring lipid guggultetrol. In: Tetrahedron, 63 (8). pp. 1798-1805.
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\gamma-Oxo-butyramides derived from tartaric acid serve as excellent precursors for the synthesis of \gamma-alkyl (aryl)-$\alpha$, $_\beta$-dihydroxy-\gamma- butyrolactones and for the synthesis of tetrols containing three contiguous stereogenic centres. The methodology presented here is general for the synthesis of \gamma-alkyl (aryl)-$\alpha$, $_\beta$-dihydroxy-\gamma-butyrolactones.Utility of the chiral building block was demonstrated by the synthesis of naturally occurring lipid guggultetrol.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||g-Butyrolactone;Stereoselective reduction;L-(+)-Tartaric acid;Guggultetrol|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||27 Mar 2007|
|Last Modified:||19 Sep 2010 04:36|
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