Charles, AK and Hisheh, S and Liu, D and Rao, RM and Waddell, BJ and Dickinson, JE and Rao, AJ and Dharmarajan, AM (2005) The expression of apoptosis related genes in the first trimester human placenta using a short term in vitro model. In: Apoptosis, 10 (1). pp. 135-140.
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Using in vitro model for studying the induction andinhibition of spontaneous apoptosis in human first trimester placental villi, mediated by the free radical scavenger SOD, we have examined the expression of bcl-xL, bax, Caspase-3 and PARP (Poly ADP-ribosyl). An increase in apoptosis was associated with activation of PARP and an increase and activation of Caspase-3. There was no significant change in bcl-x or bax. Therefore bcl-x and bax do not appear to have a significant role in apoptosis in the first trimester in vitro. Cleavage of Caspase-3 rather than transcriptional regulation appears to be the main determinant of Caspase-3 activity in first trimester placental villi.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Springer.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||03 Apr 2007|
|Last Modified:||19 Sep 2010 04:37|
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