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FSH, the neglected sibling: Evidence for its role in regulation of spermatogenesis and Leydig cell function

Sriraman, V and Rao, AJ (2005) FSH, the neglected sibling: Evidence for its role in regulation of spermatogenesis and Leydig cell function. In: Indian Journal of Experimental Biology, 43 (11). pp. 993-1000.

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Abstract

The role of follicle stimulating harmone(FSH) in male reproductive function remains a matter of debate although recent evidences strongly suggest a role despite the controversies that arose following the results obtained with FSH-\beta null mice and observations from human FSH receptor mutations. This review summarizes the recent developments of our understanding on the role of FSH in male reproduction. Specifically the results obtained with FSH-\beta and FORKO null mice are be discussed in light of our observations employing active and passive neutralization of endogenous FSH in rodents and primates along with other studies.On the basis of results obtained employing a variety of models it can be conclude unequivocally that FSH regulates Leydig cell function and is essential for normal quantitative spermatogenesis.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 26 Jun 2007
Last Modified: 09 Jan 2012 06:28
URI: http://eprints.iisc.ernet.in/id/eprint/10577

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