Kalate, Rupali N and Kulkarni, BD and Nagaraja, V (2002) Analysis of DNA curvature distribution in mycobacterial promoters using theoretical models. In: Biophysical Chemistry, 99 . pp. 77-97.
In this paper, 125 different mycobacterial promoters are analyzed for their DNA curvature distribution using several di- and tri-nucleotide dependent models of DNA curvature. Different models give similar behavior and therefore qualitative validation of the results. Mycobacterial promoters resembling the E. coli s type have almost 81% (85%) 70sequences having medium and high curvature profiles using dinucleotide-dependent models. Non-E. coli s type mycobacterial promoters have comparatively higher percent of low curvature profiles. Very few extended y10 promoters have low curvature profiles. Mycobacterial promoters having A T (nqmG3) tract in the upstream region of -35 box and repeated in phase with each other have high curvature profiles. M. smegmatis promoters have high curvature profiles compared to M. tuberculosis promoters
|Item Type:||Journal Article|
|Keywords:||Mycobacterial promoters;Transcription;Curvature models|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||06 Nov 2004|
|Last Modified:||19 Sep 2010 04:14|
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