Jain, P and Nagaraja, V (2002) An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics. In: Journal of Genetics, 81 (3). pp. 106-110.
DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role
|Item Type:||Journal Article|
|Keywords:||Mycobacterium smegmatis;gyr genes;DNA gyrase;topoisomerase;comparative genomics|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||17 Dec 2004|
|Last Modified:||19 Sep 2010 04:14|
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