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Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians

Radha, V and Vimaleswaran, KS and Babu, S and Deepa, R and Anjana, M and Ghosh, S and Majumder, PP and Rao, MRS and Mohan, V (2007) Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians. In: Diabetic Medicine, 24 (4). pp. 398-402.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-...

Abstract

Aims The aim of the study was to investigate the association of serum adiponectin levels with the Pro12Ala polymorphism of the peroxisome proliferator activated receptor-gamma (PPARG) gene in Asian Indians. Methods We selected 400 diabetic subjects, 200 with the Pro12Pro genotype (100 male and 100 female) and 200 with the Pro12Ala genotype (100 male and 100 female) and 400 age-and sex-matched normal glucose tolerance subjects with similar genotype profiles from the Chennai Urban Rural Epidemiology Study. Fasting serum adiponection levels were measured using radioimmunoassay. The Pro12Ala polymorphism was genotyped by PCR-restriction fragment length polymorphism using BstUI. Results All clinical and biochemical parameters were similar in the subjects with the Pro12Pro and Pro12Ala genotypes. There was no significant difference in serum adiponectin values between subjects with the Pro12Pro and Pro12Ala genotypes (males 5.4 vs. 5.8 mu g/ml, P = 0.546; females 6.9 vs. 7.2 mu g/ml, P = 0.748). Adiponectin values did not differ among these two genotypes even when categorized based on their diabetes status (normal glucose tolerance Pro12Pro 7.9 vs. Pro12Ala 7.7 mu g/ml, P = 0.994; diabetes Pro12Pro 4.7 vs. Pro12Ala 5.4 mu g/ml, P = 0.622).

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: adiponectin;Asian Indians;Chennai Urban Rural Epidemiology Study;Pro12Ala polymorphism;Type 2 diabetes
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 16 Jan 2008
Last Modified: 12 Jan 2012 08:57
URI: http://eprints.iisc.ernet.in/id/eprint/11172

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