Nagaraja, V (2004) Regulation of DNA topology in mycobacteria. In: Current Science, 86 (1). pp. 135-140.
DNA topoisomerases catalyse essential DNA transaction processes in order to attain the balanced topology of the genome. Contrasting activities of DNA topoisomerase I and DNA gyrase result in the maintenance of topological homeostasis. The regulation of expression of different topoisomerases ensure steady state optimum level expression of the enzymes. Many aspects of their organization and regulation seem to be different in mycobacteria when compared with that of Escherichia coli. Here we present several aspects of the regulation of mycobacterial topoisomerases and discuss the significance.
|Item Type:||Journal Article|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||22 Jul 2004|
|Last Modified:||19 Sep 2010 04:14|
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