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DNA Gyrase Genes in Mycobacterium tuberculosis: a Single Operon Driven by Multiple Promoters

Unniraman, Shyam and Chatterji, Monalisa and Nagaraja, Valakunja (2002) DNA Gyrase Genes in Mycobacterium tuberculosis: a Single Operon Driven by Multiple Promoters. In: Journal of Bacteriology, 184 (19). pp. 5449-5456.

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Abstract

The two genes encoding DNA gyrase in Mycobacterium tuberculosis are present next to each other in the genome, with gyrB upstream of gyrA. We show that the primary transcript is dicistronic. However, in addition to the principal promoter, there are multiple weaker promoters that appear to fine-tune transcription. With these and other mycobacterial promoters, we propose consensus promoter sequences for two distinct sigma factors. In addition to this, the gyr genes in M. tuberculosis, as in other species, are subject to auto regulation, albeit with slower kinetics, probably reflecting the slower metabolism of the organism.

Item Type: Journal Article
Keywords: DNA Gyrase;Mycobacterium tuberculosis
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 26 Jul 2004
Last Modified: 19 Sep 2010 04:14
URI: http://eprints.iisc.ernet.in/id/eprint/1150

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