Singh, Yashveer and Gulyani, Akash and Bhattacharya, Santanu (2003) A new ratiometric fluorescence probe as strong sensor of surface charge of lipid vesicles and micelles. In: FEBS Letters, 541 (1-3). pp. 132-136.
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We report on the ability of a new fluorescent probe, 4-(2-pyren-1-yl-vinyl) pyridine, 1, to respond to micelles and phospholipid vesicles of different surface charge. The probe gets incorporated into micellar and membranous assemblies and shows a large red-shift in the fluorescence emission maxima especially when the surface charge of the organized media is anionic. The effect on the photo-excitation of the probe is very clear and pronounced as it can be easily visualized. The sample color upon photo-excitation changes from blue to orange/red once the probe experiences negatively charged vesicular or micellar surfaces. These results make the probe molecule useful as a reporter for sensing electrostatic environment in biological membranes and related organized assemblies.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||Membrane surface charge;Ratiometric probe;Pyren-1-yl-vinyl pyridine;Anionic surface;Phospholipid vesicle;Micelle|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||25 Sep 2007|
|Last Modified:||19 Sep 2010 04:39|
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