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Recombinant hemagglutinin protein of rinderpest virus expressed in insect cells induces humoral and cell mediated immune responses in cattle

Sinnathamby, G and Naik, Sangeeta and Renukaradhya, GJ and Rajasekhar, M and Nayak, R and Shaila, MS (2001) Recombinant hemagglutinin protein of rinderpest virus expressed in insect cells induces humoral and cell mediated immune responses in cattle. In: Vaccine, 19 (28-29). pp. 3870-3876.

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Abstract

Rinderpest virus causes a highly contagious and often fatal disease in domestic and wild ruminants. The surface glycoproteins, hemagglutinin (H) and fusion (F) proteins of this enveloped virus are known to confer protective immunity in cattle. We have reported the generation of a recombinant baculovirus expressing H protein and studied its protective properties in cattle. In this report, we demonstrate that the recombinant baculovirus encoded H protein expressed in insect cells gets incorporated into extracellular baculovirus. Single administration of low doses of purified recombinant extracellular virus with or without adjuvant induces virus neutralizing antibody responses and bovine leukocyte antigen (BoLA) class II restricted helper T cell responses in cattle.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Keywords: Hemagglutinin;Immune responses;Rinderpest
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 03 Oct 2007
Last Modified: 19 Sep 2010 04:39
URI: http://eprints.iisc.ernet.in/id/eprint/12029

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