ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Idiotypic–Anti-idiotypic B Cell Interactions Generated against a Protective Antigen of a Morbillivirus in Mice

Kaushik, Shibani M and Shaila, MS and Karande, Anjali and Nayak, Rabindranath (2001) Idiotypic–Anti-idiotypic B Cell Interactions Generated against a Protective Antigen of a Morbillivirus in Mice. In: Cellular Immunology, 209 (1). pp. 10-18.

[img] PDF
Idiotypic–Anti-idiotypic.pdf
Restricted to Registered users only

Download (161Kb) | Request a copy

Abstract

The idiotypic network theory (N. K. Jerne, Ann. Immunol. 125, 373–389, 1974) predicts that any antibody that can be made by an individual would have its preexisting specific complementary B cells in its germline repertoire. We transplanted syngeneic BALB/c mice with live hybridoma cells and demonstrated the simultaneous presence of interacting idiotypic and anti-idiotypic B cells in an individual animal by immuno-cytoadherence assays. Furthermore, we demonstrate that interacting B cells displaying idiotypic and anti-idiotypic antibodies are subjected to lysis by complement. It is therefore tempting to speculate that this complement-sensitive interaction between idiotypic and complementary anti-idiotypic B cells in vivo may provide a mechanism for the regulation of B cell populations.

Item Type: Journal Article
Additional Information: The copyright of this article belongs to Academic Press
Keywords: Idiotypic antibody;anti idiotypic antibody;B cell regulation
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 03 Oct 2007
Last Modified: 19 Sep 2010 04:39
URI: http://eprints.iisc.ernet.in/id/eprint/12030

Actions (login required)

View Item View Item