Kaushik, Shibani M and Shaila, MS and Karande, Anjali and Nayak, Rabindranath (2001) Idiotypic–Anti-idiotypic B Cell Interactions Generated against a Protective Antigen of a Morbillivirus in Mice. In: Cellular Immunology, 209 (1). pp. 10-18.
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The idiotypic network theory (N. K. Jerne, Ann. Immunol. 125, 373–389, 1974) predicts that any antibody that can be made by an individual would have its preexisting specific complementary B cells in its germline repertoire. We transplanted syngeneic BALB/c mice with live hybridoma cells and demonstrated the simultaneous presence of interacting idiotypic and anti-idiotypic B cells in an individual animal by immuno-cytoadherence assays. Furthermore, we demonstrate that interacting B cells displaying idiotypic and anti-idiotypic antibodies are subjected to lysis by complement. It is therefore tempting to speculate that this complement-sensitive interaction between idiotypic and complementary anti-idiotypic B cells in vivo may provide a mechanism for the regulation of B cell populations.
|Item Type:||Journal Article|
|Additional Information:||The copyright of this article belongs to Academic Press|
|Keywords:||Idiotypic antibody;anti idiotypic antibody;B cell regulation|
|Department/Centre:||Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Microbiology & Cell Biology
|Date Deposited:||03 Oct 2007|
|Last Modified:||19 Sep 2010 04:39|
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