Kaushik, Shibani M and Shaila, MS and Karande, Anjali K and Nayak, Rabindranath (2001) Idiotype and antigen-specific T cell responses in mice on immunization with antigen, antibody, and anti-idiotypic antibody. In: Cellular Immunology, 209 (2). pp. 109-119.
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Idiotypic determinants of immunoglobulin molecules can evoke both $CD4^+$ and $CD8^+$ T responses and exist not only as the integral components of a bona fide antigen binding receptor but also as distinct molecular entities in the processed forms on the cell surface of B lymphocytes. The present work provides experimental evidence for the concept that regulation of memory B cell populations can be achieved through the presentation of idiotypic and anti-idiotypic determinants to helper and cytotoxic cell (1). The potential of B cells to present antigens to helper and cytotoxic T cells through class II and class I MHC suggests a mechanism by which both B and T cell homeostasis can be maintained. We provide evidence for the generation of idiotype- and antigen-specific Th and Tc cells upon immunization of syngenic mice with antigen or idiotypic antibody (Ab1) or anti-idiotypic antibody (Ab2). The selective activation and proliferation of the antigen-specific Th and Tc cells mediated by idiotypic stimulation observed in these experiments suggests a B-cell-driven mechanism for the maintenance of antigen-specific T cell memory in the absence of antigenic stimulation, under certain conditions.
|Item Type:||Journal Article|
|Additional Information:||The copyright of this article belongs to Academic Press|
|Keywords:||Idiotype;immunological memory;relay hypothesis|
|Department/Centre:||Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Microbiology & Cell Biology
|Date Deposited:||03 Oct 2007|
|Last Modified:||19 Sep 2010 04:40|
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