Aravinda, S and Shamala, N and Roy, Rituparna S and Balaram, P (2003) Non-protein amino acids in peptide design. In: Journal of Chemical Sciences, 115 (5 & 6). pp. 373-400.
An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the use alpha-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments and DPro–Xxx segments for nucleating of beta-hairpin structures. beta- and gamma-amino acid residues have been used to expand the range of designed polypeptide structures.
|Item Type:||Journal Article|
|Additional Information:||Journal of Chemical Sciences previously named as Proceedings of Indian Academy of Sciences (Chemical Sciences)|
|Keywords:||Peptide design;Crystal structures;C–HLO hydrogen bond;Hybrid peptides;D-amino acids;beta-amino acids|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit
Division of Physical & Mathematical Sciences > Physics
|Date Deposited:||30 Jul 2004|
|Last Modified:||19 Sep 2010 04:14|
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