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Monoclonal Antibodies to Gonadotropin-Releasing Hormone (GnRH) Inhibit Binding of the Hormone to its Receptor

Gangatirkar, Pradnya and Gangadharan, Sunil and Narendranath, Anita and Nagpal, Sushma and Salunke, Dinakar M and Karande, Anjali A (2002) Monoclonal Antibodies to Gonadotropin-Releasing Hormone (GnRH) Inhibit Binding of the Hormone to its Receptor. In: Hybridoma and Hybridomics, 21 (4). pp. 281-286.

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Official URL: http://online.liebertpub.com/doi/abs/10.1089%2F153...

Abstract

Monoclonal antibodies (MAbs) specific to gonadotropin-releasing hormone (GnRH) were obtained using different strategies of conjugation of the peptide to carrier protein and immunization. Of several antibodies obtained, two, namely F1D3C5 and E2D2 bound GnRH in solution phase. Though the epitopes corresponding to the two overlapped, there was a one amino acid shift in the core epitope. These two antibodies were characterized with respect to inhibition of GnRH induced responses in rat pituitary cultures and \alpha-T3.1 mouse gonadotrope cell line.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Mary Ann Liebert.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 15 Nov 2007
Last Modified: 07 Feb 2012 05:23
URI: http://eprints.iisc.ernet.in/id/eprint/12145

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