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Role of context in the relationship between form and function: structural plasticity of some PROSITE patterns

Mondal, Sukanta and Jaishankar, SP and Ramakumar, S (2003) Role of context in the relationship between form and function: structural plasticity of some PROSITE patterns. In: Biochemical and Biophysical Research Communications, 305 (4). pp. 1078-1084.

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Abstract

True positive hits of PROSITE sequence pattern are expected to have a characteristic three-dimensional structure. The combined sequence–structure attributes of PROSITE patterns can be used for function prediction of an uncharacterized protein with known primary and 3D structure, a situation that might arise in structural genomics projects. We have found specific examples of true hits of PROSITE patterns displaying structural plasticity by assuming significantly different local conformation, depending upon the context. Our work highlights the importance of taking into account all the known distinct conformations of PROSITE patterns, while creating a sensitive 3D template for the pattern, for use in functional annotation.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Keywords: PROSITE pattern;Protein function;Structure;Local conformational change;Structural genomics
Department/Centre: Division of Information Sciences > BioInformatics Centre
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 17 Oct 2007
Last Modified: 19 Sep 2010 04:40
URI: http://eprints.iisc.ernet.in/id/eprint/12245

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