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Novel distamycin analogues: facile synthesis of cholesterol conjugates of distamycin-like oligopeptides

Bhattacharya, Santanu and Thomas, Mini (2001) Novel distamycin analogues: facile synthesis of cholesterol conjugates of distamycin-like oligopeptides. In: Tetrahedron Letters, 42 (20). pp. 3499-3502.

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Abstract

A facile route towards the synthesis of the first examples of cholesterol-conjugated distamycin analogues is described. These compounds retain their strong binding capacity to double-stranded (ds)-DNA. Aqueous suspensions of these analogues exhibited closed, vesicle-like structures under transmission electron microscope.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 15 Oct 2007
Last Modified: 19 Sep 2010 04:40
URI: http://eprints.iisc.ernet.in/id/eprint/12257

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