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Polyvanadate acts at the level of plasma membranes through $\alpha$- adrenergic receptor and affects cellular calcium distribution and some oxidation activities

Ramasarma, T and Gullapalli, S and Shivaswamy, V and Kurup, CKR (1990) Polyvanadate acts at the level of plasma membranes through $\alpha$- adrenergic receptor and affects cellular calcium distribution and some oxidation activities. In: Journal of Biosciences, 15 (3). pp. 205-210.

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Official URL: http://medind.nic.in/imvw/imvw19433.html

Abstract

The activities of calcium-stimulated respiration, calcium uptake, $\alpha$- glycerophosphate dehydrogenase and rates of oxidation in state 3 and of H2O2 generation, were found to increase and that of pyruvate dehydrogenase decrease in mitochondria isolated from livers of rats administered intraperitoneally or perfused with Polyvanadate. Phenoxybenzamine, an antagonist of $\alpha$-adrenergic receptor, effectively prevented these changes. It was also found that perfusion of the liver with Polyvanadate reproduced one of best characterized events of $\alpha$-adrenergic activation-stimulation of protein kinase C in plasma membrane accompanied by its decrease in cytosol. These experiments indicate for the first time the $\alpha$-adrenergic mimetic action of polyvanadate.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Science.
Keywords: Cell membrane/US;Receptor;Adrenergic;Alpha/BI;Mitochondria/US;Liver;Protein Kinase C/SE;Catecholamines;Cytosol;Calcium/BI;Phenoxybenzamine;Metabolism Signal Transudation/DE; Animals;Rats.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 17 Dec 2007
Last Modified: 08 Feb 2012 05:26
URI: http://eprints.iisc.ernet.in/id/eprint/12508

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