Vasanthakumar, Ganga Ramu and Bhor, Vikrant M and Surolia, Avadhesha (2007) Hydrolysis of Cyclic Ureas under Microwave Irradiation: Synthesis and Characterization of 7,8-Diaminopelargonic Acid. In: Synthetic Communications, 36 (16). 2633 -2639.
Hydrolysis_of_Cyclic.pdf - Published Version
Restricted to Registered users only
Download (85Kb) | Request a copy
A simple and efficient method for the synthesis of 7,8-diaminopelargonic acid, a key intermediate in the biotin biosynthesis pathway, is reported. The d-desthiobiotin powder was dissolved in concentrated hydrochloric acid, and the solution was exposed to microwave radiation of 2.45 GHz for varying lengths of time ranging from 60 s to 2 min. The product thus obtained was characterized by spectroscopic techniques and confirmed through bioassay. Further, the protocol was extended to the synthesis of several diamines from their corresponding cyclic ureas. The results show that the method is generally applicable and not only accelerates the hydrolysis reaction but also offers excellent yields.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Taylor and Francis Group.|
|Keywords:||acid hydrolysis;cyclic urea;d‐desthiobiotin;7,8‐diaminopelargonic acid;microwave irradiation|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||19 Nov 2007|
|Last Modified:||08 Feb 2012 05:32|
Actions (login required)