Deniz, Usha K and Parvathanathan, PS and Datta, Geeta and Khetrapal, CL and Ramanathan, KV and Suryaprakash, N and Raghotama, S (1990) Nuclear magnetic resonance and thermal studies of drug doped dipalmitoyl phosphatidyl choline-$H_2O$ systems. In: Journal of Biosciences, 15 (3). pp. 117-123.
The influence of the sulfone drugs, diamino diphenyl sulfone and diamino monophenyl sulfone on the phase transitions and dynamics of dipalmitoyl phosphatidyl choline-$H_2O/D_2O$ vesicles have been investigated using differential scanning calorimetry and nuclear magnetic resonance. Our results show that diamino diphenyl sulfone interacts quite strongly with the headgroups of dipalmitoyl phosphatidyl choline whereas the diamino monophenyl sulfone-dipalmitoyl phosphatidyl choline interaction is quite weak. This is attributed to the difference in the structure and hydrophobic character of the two drugs.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Indian Academy of Science|
|Keywords:||Dipalmitoyl phosphatidyl choline;drug-membrane interaction;differential scanning calorimetry;1H NMR;31P NMR.|
|Department/Centre:||Division of Chemical Sciences > Sophisticated Instruments Facility|
|Date Deposited:||19 Dec 2007|
|Last Modified:||05 Jan 2011 07:18|
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