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Spectroscopic studies on the structure and aggregation of calcium ionophore, A23187

Easwaran, KRK and Balasubramanian, SV (1990) Spectroscopic studies on the structure and aggregation of calcium ionophore, A23187. In: 5th Proceedings UNESCO International Conference, 1989.

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Abstract

Studies on the structure of calcium ionophore, A23187, using IR, UV, CD, fluorescence and NMR methods indicated that this ionophore forms a dimer in nonpolar solvents such as chloroform. When incorporated into a phospholipid vesicle, the spectra showed remarkable time dependent changes indicating further aggregation of the dimer into a stacked dimeric structure in dipalmitoylphosphatidylcholine vesicle. Results point to the possibility of A23187 transporting divalent cations across membranes by a pore rather than by a diffusive carrier model.

Item Type: Conference Proceedings
Additional Information: Copyright of this article belongs to Birkhaeuser.
Keywords: Spectroscopic studies;calcium ionophore;fluorescence;NMR methods
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 28 Dec 2007
Last Modified: 08 Feb 2012 07:24
URI: http://eprints.iisc.ernet.in/id/eprint/12575

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