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Effect of modulating endogenous prolactin secretion on testosterone production in the adult male bonnet monkey (Macaca radiata)

Rao, AJ and Rani, CS and Ravindranath, N and Moudgal, NR (1990) Effect of modulating endogenous prolactin secretion on testosterone production in the adult male bonnet monkey (Macaca radiata). In: Andrologia, 22 (3). pp. 251-259.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1439-...

Abstract

Adult male bonnet monkeys maintained under regulated light:dark conditions exhibit a nycthemeral surge of testosterone. The present study attempts to det. the effect of administration of drugs that modulate prolactin levels like ergobromocriptine (EBC) and chlorpromazine (CPZ) on testosterone prodn. The injection of EBC, a known inhibitor of prolactin secretion, could abolish nocturnal testosterone surge irresp. of the drug being given at 8.00 or 17.00 h. Testosterone surge could likewise be inhibited by treating animals with CPZ, a potent stimulator of prolactin secretion. This suggests that alteration in endogenous prolactin level from the normal effects nycthemeral surges of testosterone. The in vivo responsiveness of the testes of monkeys injected with either CPZ or EBC to exogenous LH or LHRH stimulation was tested. While LH could completely override the CPZ induced inhibition in testosterone prodn. it could only partially reverse the EBC effect.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: Prolactin;testisfunction;testosterone;chlorpromazine;prolactin;ergobromocriptine;prolactin testicular function;prolactin
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Date Deposited: 28 Dec 2007
Last Modified: 08 Feb 2012 07:40
URI: http://eprints.iisc.ernet.in/id/eprint/12581

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