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Transcriptional regulation of cytochrome P-450b/e gene expression in rat liver

Padmanaban, G and Rangarajan, PN and Venkateswar, V and Rao, Venkateswara M and Upadhya, Poornima (1990) Transcriptional regulation of cytochrome P-450b/e gene expression in rat liver. In: Biological Oxidation system (Proceedings symposium), 1989.

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Abstract

The regulatory features of the transcriptional activation of the cytochrome P-450IIB1/B2(b/e) genes in rat liver by phenobarbitone have been examd. Heme as a pos. modulator, and dexamethasone modulator of the action of the pos. activator were examd. The upstream sequence within -179 nucleotides of the cytochrome P-450b/e genes has been found to respond to the various regulatory features mentioned. Apparently, phenobarbitone induces a set of transcription factors leading to the transcriptional activation of the P-450b/e genes in rat liver. Conditions resulting in an interference with the-drug mediated increase in transcription are invariably assocd. with a decrease in the interaction of 90Kd proteins with an upstream sequence. The cytochrome P-450b/e genes also manifest elongation regulation at the level of transcription.

Item Type: Conference Proceedings
Additional Information: Copyright of this article belongs to Academic.
Keywords: Transcriptional regulation;cytochrome;rat liver;phenobarbitone
Department/Centre: Others
Date Deposited: 27 Dec 2007
Last Modified: 08 Feb 2012 07:19
URI: http://eprints.iisc.ernet.in/id/eprint/12584

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