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Determinants of histamine recognition: Implications for the design of antihistamines

Konkimalla, Badireenath V and Chandra, Nagasuma (2003) Determinants of histamine recognition: Implications for the design of antihistamines. In: Biochemical and Biophysical Research Communications, 309 (2). pp. 425-431.

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Abstract

Towards understanding how histamine, a vital neurotansmitter, can perform multiple physiological tasks, an analysis of the different proteins that bind histamine is reported here. Their structural comparison reveals conformational rigidity of histamine. Yet, flexibility in the modes of histamine binding has been observed, which appears to suit specific biological roles of the proteins. These results will be helpful in developing specific antihistamines and also in understanding the pharmacological and toxicological profiles of existing antihistamines

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Inc.
Keywords: Histamine;Binding modes;Structural comparison;Structural determinants;Side effects;Specific design
Department/Centre: Division of Information Sciences > BioInformatics Centre
Date Deposited: 04 Feb 2008
Last Modified: 19 Sep 2010 04:41
URI: http://eprints.iisc.ernet.in/id/eprint/12632

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