Kasturi, TR and Jois, HRY (1990) Synthesis of 7-alkyl-4-cyano-3-methoxy-1-methyl-5,6-dihydroisoquinoline. In: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 29 (7). pp. 615-619.Full text not available from this repository. (Request a copy)
Knoevenagel condensation of 2-acylcyclohexanones with cyanoacetamide followed by silver salt methylation gives 5,6,7,8-tetrahydroisoquinolines I (R = H, Me, Me3C). Chromic acid oxidn. of I leads to tetralones, which were reduced with borohydride and the alcs. dehydrated by p-toluenesulfonic acid to give the corresponding 5,6-dihydroisoquinolines II (same R).
|Item Type:||Journal Article|
|Additional Information:||The copyright belongs to National Institute of Science Communication and Information Resources|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||11 Feb 2008|
|Last Modified:||27 Aug 2008 13:07|
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