Balaji, KN and Nayak, R (1992) Effect of 5-fluorouracil on interleukin-2 expression. In: Biochemical and Biophysical Research Communications, 187 (1). pp. 305-309.
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The effect of 5-fluorouracil on the expression of IL-2 gene and the production of IL-2 protein has been studied using spleenic lymphocytes of rats. The IL-2 messenger RNA has been quantitated by dot-blots and IL-2 has been assayed by Con A-blast assay. The results show that there is up to 3.75 fold increase in the production of IL-2 message in 5-fluorouracil treated lymphocytes over Con A treated controls. There is also a concomitant increase in IL-2 protein production upon 5-fluorouracil treatment in rat lymphocytes.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Inc.|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||12 Feb 2008|
|Last Modified:||19 Sep 2010 04:41|
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