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Increase in glycerophosphate dehydrogenase and other oxidoreductase activities of hepatic mitochondria on administration of vanadate to the rat

Gullapalli, Sharada and Shivaswamy, Vidya and Ramasarma, T and Ramakrishna, CK (1989) Increase in glycerophosphate dehydrogenase and other oxidoreductase activities of hepatic mitochondria on administration of vanadate to the rat. In: Indian Journal of Biochemistry & Biophysics, 26 (4). pp. 227-233.

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Abstract

Liver mitochondria isolated from vanadate-administered rats showed increased (20-25%) rates of oxidn. of both NAD-linked substrates and succinate. Respiratory control index and ADP/O were unaffected by the treatment. Dormant and uncoupler-stimulated ATPase activity also was not affected by vanadate administration. Membrane-bound, electron transport-linked dehydrogenase activities (both NAD- and succinate-dependent) increased by 15-20% on vanadate treatment. Mitochondrial \alpha-glycerophosphate dehydrogenase activity increased by 50% on vanadate administration. The above effects of vanadate on oxidoreductase activities could be prevented by the prior administration of antagonists to \alpha-adrenergic receptors. Substrate-dependent H2O2 generation by mitochondria also showed an increase on vanadate administration

Item Type: Journal Article
Additional Information: The copyright belongs to National Institute of Science Communication and Information Resources
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 22 Feb 2008
Last Modified: 27 Aug 2008 13:08
URI: http://eprints.iisc.ernet.in/id/eprint/12783

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