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A23187 (Calcimycin): Structure and Interaction in Relation to its Transmembrane Calcium-ion Transport

UNSPECIFIED (1992) A23187 (Calcimycin): Structure and Interaction in Relation to its Transmembrane Calcium-ion Transport. In: The Proceedings of the Indo-U.S. Workshop, 1991, Bangalore.

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Abstract

Studies using IR, UV, CD, fluorescence, and NMR techniques on the calcium ionophore A23187 (calcimycin) under various conditions clearly showed that the mol. exists as a stable dimer in nonpolar solvents and aggregates further into a stacked dimeric pore structure in phospholipid vesicles. Results indicated the possibility of transmembrane calcium ion transport by this ionophore also by a pore mechanism in addn. to the carrier type. Bilayer membrane conductance expts. with A23187 incorporated into lipid bilayer gave single channel current in the picoampere range. The current characteristics showed the existence of both carrier and channel properties for ion transport by this ionophore.

Item Type: Conference Proceedings
Additional Information: Copyright of this article belongs to Adenine Press
Keywords: fluorescence;NMR techniques;calcium ionophore
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 14 Feb 2008
Last Modified: 27 Aug 2008 13:08
URI: http://eprints.iisc.ernet.in/id/eprint/12798

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