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Non-standard amino acids in peptide design and protein engineering

Balaram, Padmanabhan (1992) Non-standard amino acids in peptide design and protein engineering. In: Current Opinion in Structural Biology, 2 (6). pp. 845-851.

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Official URL: http://dx.doi.org/doi:10.1016/0959-440X(92)90110-S

Abstract

The introduction of non-coded amino acids with well defined stereochemical and functional properties will greatly enhance the scope of protein design and engineering. The present state of methodologies for incorporation of non-coded residues into proteins is examined. The prospects for conformationally constrained amino acid residues are evaluated in the light of peptide structural studies. Templates for secondary-structure nucleation and recent experiences in the incorporation of novel residues into proteins are considered.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science Ltd.
Keywords: amino-cycloalkane-1-carboxylic acid;α-aminoisobutyric acid;human immunodeficiency virus;lactic acid;pipecolic acid
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 19 Feb 2008
Last Modified: 22 Dec 2010 10:18
URI: http://eprints.iisc.ernet.in/id/eprint/12878

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