Balaram, Padmanabhan (1992) Non-standard amino acids in peptide design and protein engineering. In: Current Opinion in Structural Biology, 2 (6). pp. 845-851.
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The introduction of non-coded amino acids with well defined stereochemical and functional properties will greatly enhance the scope of protein design and engineering. The present state of methodologies for incorporation of non-coded residues into proteins is examined. The prospects for conformationally constrained amino acid residues are evaluated in the light of peptide structural studies. Templates for secondary-structure nucleation and recent experiences in the incorporation of novel residues into proteins are considered.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science Ltd.|
|Keywords:||amino-cycloalkane-1-carboxylic acid;α-aminoisobutyric acid;human immunodeficiency virus;lactic acid;pipecolic acid|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||19 Feb 2008|
|Last Modified:||22 Dec 2010 10:18|
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