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Role of calcium in secretion of chorionic gonadotropin by first trimester human placenta.

Sharma, SC and Rao, AJ (1992) Role of calcium in secretion of chorionic gonadotropin by first trimester human placenta. In: Indian journal of experimental biology, 30 (11). pp. 1105-1110.

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Abstract

The role of calcium in regulation of secretion of human chorionic gonadotropin (hCG) by first trimester human placental minces in vitro has been investigated. Depletion of calcium in the medium by addition of EGTA resulted in a drastic decrease in the levels of immunoreactive hCG in the medium with consequent of accumulation of hCG in the tissue. Addition of A 23187 which is a calcium ionophore resulted in a dose dose dependent increase in the hCG in the medium and this stimulatory response could not be observed in the absence of calcium. Use of lanthanum (a calcium antagonist) in place of calcium in the medium used resulted in a significant decrease in the levels of hCG in the medium. Addition of veratridine (a sodium channel activator) stimulated hCG secretion in a dose dependent manner. These results suggest that calcium is essential for normal secretion of hCG by human placenta.

Item Type: Journal Article
Additional Information: The copyright belongs to National Institute of Science Communication and Information Resources
Keywords: calcium;chorionic gonadotropin;human placenta
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 26 Feb 2008
Last Modified: 27 Aug 2008 13:09
URI: http://eprints.iisc.ernet.in/id/eprint/12883

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