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Why do DNA helical models exhibit wedge rolls? A mathematical rationale

Bhattacharyya, Dhananjay and Bansal, Manju (1988) Why do DNA helical models exhibit wedge rolls? A mathematical rationale. In: Current Science, 57 (21). pp. 1159-1162.

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Abstract

The base-pair parameters wedge-tilt and wedge-roll are extremely useful for describing curved DNA structures. The wedge effect has generally been assumed to be due to the differences between the base-pair tilts and rolls of two successive base-pairs in a DNA molecule. A mathematical formalism has been established here, which shows that, wedgc-roll is a function of basepair tilt and helical twist, similarly the wedge-tilt is a function of base-pair roll and helical twist. This provides a straightforward explanation for the reported wedge-roll in A-DNA helical model of $12^0$ and gives a value of $-3.8^0$ for B-DNA fiber model. The wedge-rolls and wedgetilts calculated for the oligonucleotide crystal structures, using these relations, are in excellent agreement with the values reported earlier, which were .calculated directly from the coordinates, using a global helix axis.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Science.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 21 Feb 2008
Last Modified: 19 Sep 2010 04:42
URI: http://eprints.iisc.ernet.in/id/eprint/13074

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