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Structure of S-(p-Nitrobenzyl)-6-Thioguanosine

Mande, Sharmila S and Seshadri, TP and Viswamitra, MA (1988) Structure of S-(p-Nitrobenzyl)-6-Thioguanosine. In: Current Science, 57 (9). pp. 923-925.

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Abstract

The crystal structure of S-(p-nitrobenzy1)-6-thioguanosine has been determined. The crystal belongs to the monoclinic system with a = 7.299(1), b = 8.825(2), c = 14.565(1) \AA, \beta = 94.78(1)°. There is one molecule in the asymmetric unit. The structure is solved by direct methods and refined to an R-factor of 0.031. The molecule has syn guanosinc base, C(2')-endo sugar pucker and gauche-gauche conformation about the C(4')-C(5') bond. The torsion angle about S-C(9) bond bridging the base and the benzene ring is - 77.6(3)°. The crystal structure is stabilized by an N(3) ... O(5') intramolecular hydrogen bond in addition to several intermolecular hydrogen bonds. Although the crystal structure shows no base-base stacking, thc exocyclic atoms N(13) and O(1) of the phenyl ring show close stacking contacts with thc guanosine base of the $2_1$ related molecule.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 04 Mar 2008
Last Modified: 19 Sep 2010 04:42
URI: http://eprints.iisc.ernet.in/id/eprint/13128

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