Seelan, Sathiagana R and Padmanaban, Govindarajan (1988) A processed pseudogene with an intact coding sequence for rat liver cytochrome c oxidase subunit VIc. In: Gene, 67 (1). pp. 125-130.
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The biogenesis of eukaryotic cytochrome c oxidase involves the coordinate expression of nuclear and mitochondrial genes. Very little information is available on the gene structure of nuclear-coded cytochrome c oxidase subunits in mammalian systems. We report here the isolation and complete nucleotide sequence determination of a processed pseudogene for cytochrome c oxidase subunit VIc from rat liver. The pseudogene lacks introns and the coding region is intact with no deleterious lesions; however, there are 7 amino acid (aa) differences when compared to the sequence derived from cDNA clones. The pseudogene has the potential to code for a protein of 76 aa, containing a putative 3 aa N-terminal presequence when compared to the mature bovine heart VIc subunit. Potential regulatory regions, including a TATA box, are present in the 5′-flanking region.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||29 Feb 2008|
|Last Modified:||19 Sep 2010 04:43|
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