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A processed pseudogene with an intact coding sequence for rat liver cytochrome c oxidase subunit VIc

Seelan, Sathiagana R and Padmanaban, Govindarajan (1988) A processed pseudogene with an intact coding sequence for rat liver cytochrome c oxidase subunit VIc. In: Gene, 67 (1). pp. 125-130.

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Abstract

The biogenesis of eukaryotic cytochrome c oxidase involves the coordinate expression of nuclear and mitochondrial genes. Very little information is available on the gene structure of nuclear-coded cytochrome c oxidase subunits in mammalian systems. We report here the isolation and complete nucleotide sequence determination of a processed pseudogene for cytochrome c oxidase subunit VIc from rat liver. The pseudogene lacks introns and the coding region is intact with no deleterious lesions; however, there are 7 amino acid (aa) differences when compared to the sequence derived from cDNA clones. The pseudogene has the potential to code for a protein of 76 aa, containing a putative 3 aa N-terminal presequence when compared to the mature bovine heart VIc subunit. Potential regulatory regions, including a TATA box, are present in the 5′-flanking region.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 29 Feb 2008
Last Modified: 19 Sep 2010 04:43
URI: http://eprints.iisc.ernet.in/id/eprint/13169

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