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Increase in hepatic ubiquinone on administration of diethylhexyl phthalate to the rat

Nair, Nandini and Kurup, Ramakrishna CK (1987) Increase in hepatic ubiquinone on administration of diethylhexyl phthalate to the rat. In: Journal of Biosciences, 11 (1-4). 391 -7.

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Abstract

The content of ubiquinone of liver increases (2.5-fold) on dietary administration of the widely-used industrial plasticizer di(2-ethylhexyl) phthalate (I) to the rat. The increase is localized almost entirely in mitochondria in which the concn. of the quinone per mg protein is 1.7 times the control. Incorporation of the radioactive precursor (acetate) reveals that the biosynthesis of ubiquinone is increased in the livers of plasticizer-administered animals. The rate of degrdn. is not altered.

Item Type: Journal Article
Additional Information: Copyright belongs to The Indian Academy of Sciences
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 14 Mar 2008
Last Modified: 27 Aug 2008 13:14
URI: http://eprints.iisc.ernet.in/id/eprint/13258

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