Ravindranath, NH and Moudgal, NR (1987) Use of tamoxifen, an antiestrogen, in establishing a need for estrogen in early pregnancy in the bonnet monkey (Macaca radiata). In: Journal of Reproduction and Fertility, 81 (2). pp. 327-336.
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Administration of tamoxifen orally (3 mg/kg/day) during the post-ovulatory period from Days 16 to 20 or from Days 18 to 30 of female bonnet monkeys mated between Days 9 and 14 of the cycle resulted in inhibition of pregnancy establishment in 90-100% of monkeys tested. The pregnancy establishment in control female monkeys after exposure to the male during one ovulatory cycle was 66%. The effect of tamoxifen was not due to interference with luteal function because there was no reduction in serum progesterone concentrations after drug treatment. Exogenously administered progesterone could not reverse the inhibitory effect of tamoxifen on pregnancy establishment. The effect of tamoxifen was dose-dependent. We suggest that tamoxifen could be developed as an effective post-ovulatory contraceptive for regulation of female fertility.
|Item Type:||Journal Article|
|Additional Information:||Copyright belongs to The Society for Reproduction and Fertility.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||14 Mar 2008|
|Last Modified:||22 Oct 2010 10:17|
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