Unni, Emmanual and Kssari, KV and Rao, MRS (1984) Effect of vitamin A deprivation on the mitogenic factor activity in the rat testes. In: Biochemical and Biophysical Research Communications, 125 (2). pp. 454-462.
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The seminiferous tubules of rat testes contain a protease and heat sensitive factor capable of stimulating $(^3H)$-thymidine incorporation into quiescent cultures of NIH 3T3 mouse fibroblast cells. This mitogenic factor activity was only 4% in the testes of vitamin A deficient-retinoic acid maintained rats as compared to that of normal rats. Supplementation of retinyl acetate to these vitamin A deficient rats for 4 days resulted in a 56% recovery in the mitogenic factor activity while by day 16, the recovery was 80 percent. Incorporation of $(^3H)$-thymidine into DNA of the seminiferous tubules of vitamin A deficient rats was only 46% of that of normal rats which was restored to normal levels by retinyl acetate supplementation for 24 days.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Inc.|
|Department/Centre:||Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Microbiology & Cell Biology
|Date Deposited:||19 Mar 2008|
|Last Modified:||19 Sep 2010 04:43|
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