Veluraja, K and Rao, VSR (1984) Studies on the conformations of sialyloligosaccharides and implications on the binding specificity of neuraminidases. In: Journal of Biosciences, 6 (5). pp. 625-634.
Theoretical investigations, using semi-empirical potential functions have been carried out to predict the favoured conformations of the terminal dissaccharide fragments of various sialyloligosaccharides. The proposed conformational similarity for these fragments has been correlated to the binding specificity of neuraminidases. These calculations predict that bacterial neuraminidases have a binding site which can accommodate only two sugar residues and virus neuraminidases have a binding site which can accommodate more than two sugar residues.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Indian Academy of Sciences.|
|Keywords:||Conformation;N-acetylneuraminic acid;neuraminidases;sialic acid;sialyloligosaccharides|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||25 Mar 2008|
|Last Modified:||19 Sep 2010 04:43|
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