Madhusudan, K and Ramesh, V and Nagaraja, V (1994) Cloning and sequence analysis of DNA gyrase genes from Mycobacterium tuberculosis. In: Current Science, 66 (9). pp. 664-667.
Using a heterologous DNA gyrase probe from Streptomyces sphaeroides, we have cloned the gyrA and gyrB genes of Mycobacterium tuberculosis. The M. tuberculosis gyrB gene has been sequenced and compared with the amino acid sequences of GyrB from other bacteria. There is a significant level (60-80%) of amino acid sequence homology between GyrB of M tuberculosis and that of other bacterial species, indicating a high degree of conservation of this essential enzyme.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Indian Academy of Sciences|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||03 Apr 2006|
|Last Modified:||19 Sep 2010 04:14|
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