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Base-base interactions in nucleic acids containing A-T base pairs Structure of poly[d(A—T)]

Rajagopalan, Malini and Gupta, Goutam and Sasisekharan, V (1983) Base-base interactions in nucleic acids containing A-T base pairs Structure of poly[d(A—T)]. In: FEBS Letters, 159 (2). pp. 285-289.

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Abstract

The Watson-Crick type of base pairing is considered to be mandatory for the formation of duplex DNA. However, conformational calculations carried out in our laboratory, have shown that some combinations of backbone torsion angles and sugar pucker lead to duplexes with Hoogsteen type of base pairing also. Here we present the results of energy calculations performed on A-T containing doublet sequences in the D-form with both Hoogsteen and Watson-Crick type of base pairing and the 3 viable models for the A-T containing polynucleotide duplex poIy[d(A-T)].

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science
Keywords: Base-base interaction;Watson-Crick basepair;Hoogsteen basepairs;Poly [d(A—T)]
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 03 Apr 2008
Last Modified: 19 Sep 2010 04:44
URI: http://eprints.iisc.ernet.in/id/eprint/13562

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