Nair, Nandini and Kurup, Ramakrishna CK (1986) Investigations on the Mechanism of the Hypocholesterolemic Action of Diethylhexyl Phthalate in Rats. In: Biochemical Pharmacology, 35 (20). pp. 3441-3447.
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The plasticizer di(2-ethylhexyl)phthalate (DEHP), used widely in the manufacture of food packages and medical plastic devices, depressed serum cholesterol (40%) and proliferated hepatic mitochondria (100%) when administered in the diet (2%, w/w) to the rat. Microsomes isolated from the livers of animals administered DEHP showed lowered specific activity of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (50%). The incorporation of acetate but not of mevalonate into hepatic cholesterol was decreased (52%) in these animals. The release of bile acids was greatly enhanced (100%), and the activity of cholesterol 7\alpha-hydroxylase, the regulatory enzyme in the pathway of bile acid formation, was stimulated (70%) on DEHP administration. Even though the capacity of mitochondria to oxidize the side chain of cholesterol was not enhanced in DEHP-fed animals, the larger population of mitochondria would ensure that the amount of cholesterol oxidized pergram of liver was significantly higher.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science Inc.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||03 Apr 2008|
|Last Modified:||19 Sep 2010 04:44|
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