Sivaramakrishnan, S and Ramasarma, T (1983) Noradrenaline stimulates succinate dehydrogenase through \beta -adrenergic receptors. In: Indian Journal of Biochemistry & Biophysics, 20 (1). pp. 16-22.Full text not available from this repository. (Request a copy)
Administration of noradrenaline (I) [51-41-2] to rats increased activities of succinate dehydrogenase (EC 220.127.116.11) [9002-02-2], succinate-neotetrazolium reductase [37217-40-6], and succinate oxidase [9014-35-1] in mitochondria obtained from liver, but not kidney and heart. The max. stimulation was obtained 2 h after treatment with the hormone. The stimulation required a crit., narrow range of I concn. The action of I was sensitive to propranolol, a \beta-adrenergic blocking agent. Treatment with theophylline and glucagon, known to increase intracellular concn. of cyclic AMP [60-92-4], and with 3,4-dihydroxyphenyl serine, known to be decarboxylated to I in cytosol, also showed a similar stimulation of succinate dehydrogenase. These studies provide an interesting example of stimulation of an enzyme on treatment of animals with I by a combined \beta-receptor and possible cytosolic levels of action of the hormone.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to National Institute of Science Communication and Information Resources|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||15 Apr 2008|
|Last Modified:||27 Aug 2008 13:19|
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