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Biological characteristics of a factor suppressing follicle stimulating hormone (inhibin) from ovine testes

Murthy, Shashidhara HM and Moudgal, NR (1983) Biological characteristics of a factor suppressing follicle stimulating hormone (inhibin) from ovine testes. In: Journal of Biosciences, 5 (2). pp. 115-123.

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Abstract

Inhibin (follicle stimulating hormone suppressing factor) isolated from ovine testes has been characterized for its biological activity using a variety of tests. The bioassay used — inhibition of the human chorionic gonadotropin induced increment in the mouse uterine weight-demonstrates that there is a significant increment in specific activity (approx. 300-fold) with the progress of purification. Eventhough the final product has not been obtained in a homogenous state it has been possible to show that(a) $[^{125}I]$-labelled inhibin is preferentially taken up and retained by the pituitary, pretreatment of rats with testosterone facilitating this uptake;(b) it is able to suppress specifically the levels of follicle stimulating hormone in castrated as well as immature intact rats and (c) treatment of immature male rats with inhibin preparation for ten days results in impairment of testicular function as judged $by^3H-thymidine$ incorporation into testicular DNA and testicular hyaluronidase activity.

Item Type: Journal Article
Additional Information: Copyright belongs to Spinger.
Keywords: Regulation of FSH;testicular function;gonadotropin
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 11 Apr 2008
Last Modified: 27 Aug 2008 13:19
URI: http://eprints.iisc.ernet.in/id/eprint/13689

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