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Synthesis of a distamycin analog: tris(m-benzamido) compound

Rajagopal, Malini and Rao, Kekambareswara and Ayyer, Jayalekshmy and Sasisekharan, V (1987) Synthesis of a distamycin analog: tris(m-benzamido) compound. In: Indian Journal of Chemistry, Sect. B: Organic Chemistry including Medicinal Chemistry, 26 (11). pp. 1021-1024.

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Abstract

Distamycin analog I was prepared in order to examine its DNA binding properties. Thus, condensation of $3-O_2NC_6H_4COCl$ with $3-H_2NC_6H_4CO_2Me$ (II), sapon., acid chlorination, and recondensation with II gave $3-O_2NC_6H_4CONHC_6H_4CO_2Me$ (III). Sapon. of III, acid chlorination, condensation with $H_2NCH_2CH_2CN$, hydrolysis, hydrogenation, and formylation gave I.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Council of Scientific & Industrial Research
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 18 Apr 2008
Last Modified: 27 Aug 2008 13:20
URI: http://eprints.iisc.ernet.in/id/eprint/13763

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