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Effect of starvation on degradation of rat liver proteins

Venkatakrishna, Shyamala (1984) Effect of starvation on degradation of rat liver proteins. In: International Journal for Vitamin and Nutrition Research, 54 (4). pp. 393-399.

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Abstract

Studies on rats showed rapid loss in liver weight and proteins during starvation. This was reflected in loss of protein in most organelles including mitochondria, microsomes, and cytosol, with the exception of nuclei. The nuclear proteins increased per unit weight of liver during starvation and this held true for both histone and non-histone fractions. Comparison of degradation pattern of histone and non-histone fractions with microsomal fraction indicated a significantly different profile. The nuclear proteins reflected a pattern of decreased degradation during starvation. The increase in the activity of lysosomal cathepsin D [9025-26-7] measured during this period was indicative of general increase in catabolic processes. However, the nuclear protease [9001-92-7] activity decreased during this period, suggesting an organelle compartmentation of degradation process.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Verlag Hans Huber, Bern.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 07 May 2008
Last Modified: 27 Aug 2008 13:21
URI: http://eprints.iisc.ernet.in/id/eprint/13844

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