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Importance of sugar ring geometry in protein-nucleoside interactions

Suryaprakash, N and Ramanathan, KV and Datta, Geeta and Gurnani, S and Khetrapal, CL (1984) Importance of sugar ring geometry in protein-nucleoside interactions. In: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 23 (12). pp. 1145-1147.

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Abstract

The interaction of cytidine with lysozyme was studied by using NMR spectroscopy. The binding of the nucleoside affected the histidine-15 residue of lysozyme. An upfield shift of the proton resonance of the histidine-15 $C_2$-proton suggests stacking of the aromatic ring of cytidine over the histidine residue. The results indicate the importance of sugar geometry in the binding process.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Council of Scientific & Industrial Research.National Institute of Science Communication and Information Resources, CSIR.
Department/Centre: Division of Chemical Sciences > Sophisticated Instruments Facility
Date Deposited: 12 May 2008
Last Modified: 27 Aug 2008 13:22
URI: http://eprints.iisc.ernet.in/id/eprint/13932

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