Novel transformations of progesterone by a Mucor sp

Madyastha, Madhava K and Srivatsan, Jayanthi (1987) Novel transformations of progesterone by a Mucor sp. In: Canadian Journal of Microbiology, 33 (5). pp. 361-365.

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Abstract

A $Mucor$ sp. isolated from soil and identified as $Mucor$ $piriformis$ was used to study the mode of transformation of progesterone. Major metabolites isolated and identified were 14 \alpha -hydroxyprogesterone, 7 \beta , 14 \alpha -dihydroxyprogesterone, 7 \alpha, 14 \alpha -dihydroxyprogesterone, and 6 \beta , 14 \alpha -dihydroxyprogesterone. Among the minor metabolities, 5 \beta, 14 \alpha -dihydroxy-pregnane-3, 20-dione has been characterized. Time-course studies of the formation of transformation products showed that hydroxylation at the 14 \alpha -position is the first step in the formation of dihydroxyprogesterones. The formation of 7 \beta , 14 \alpha -dihydroxyprogesterone and 5 \beta , 14 \alpha -dihydroxypregnane-3, 20-dione represents novel transformations by $Mucor$ species.

Item Type: Journal Article Publisher Copyright for this article belongs to the NRC Research Press Division of Chemical Sciences > Organic Chemistry 13 May 2008 07 Oct 2010 10:24 http://eprints.iisc.ernet.in/id/eprint/13951