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Hypocholesterolemic action of 1-ethoxysilatrane

Mehta, Prashant P and Ramasarma, T and Kurup, Ramakrishna CK (1987) Hypocholesterolemic action of 1-ethoxysilatrane. In: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 920 (1). pp. 102-104.

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Abstract

Intraperitoneal administration of the organosilicon compound 1-ethoxysilatrane to the rat caused a 25% decrease in the concentration of cholesterol in serum without affecting that of triacylglycerols. The specific activity of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, was depressed in hepatic microsomes of silatrane-treated animals.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the Elsevier
Keywords: Ethoxysilatrane;Hydroxymethylglutaryl coenzyme A reductase;Hypocholesterolemia;Triacylglycerol;Rat hepatic microsomes
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 14 May 2008
Last Modified: 19 Sep 2010 04:44
URI: http://eprints.iisc.ernet.in/id/eprint/13978

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