Mehta, Prashant P and Ramasarma, T and Kurup, Ramakrishna CK (1987) Hypocholesterolemic action of 1-ethoxysilatrane. In: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 920 (1). pp. 102-104.
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Intraperitoneal administration of the organosilicon compound 1-ethoxysilatrane to the rat caused a 25% decrease in the concentration of cholesterol in serum without affecting that of triacylglycerols. The specific activity of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, was depressed in hepatic microsomes of silatrane-treated animals.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to the Elsevier|
|Keywords:||Ethoxysilatrane;Hydroxymethylglutaryl coenzyme A reductase;Hypocholesterolemia;Triacylglycerol;Rat hepatic microsomes|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||14 May 2008|
|Last Modified:||19 Sep 2010 04:44|
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