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NMR Investigation of the Bound Conformation of Natural and Synthetic Oligomannosides to Banana Lectin

Clavel, Caroline and Canales, Angeles and Gupta, Garima and Canada, Javier F and Penades, Soledad and Surolia, Avadhesha and Jimenez, Jesus B (2007) NMR Investigation of the Bound Conformation of Natural and Synthetic Oligomannosides to Banana Lectin. In: European Journal of Organic Chemistry, 2007 (10). pp. 1577-1585.

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Abstract

The conformational behaviour of three mannose-containing oligosaccharides, namely, the $\alpha1 \rightarrow 3[\alpha1 \rightarrow 6]$ trisaccharide, a heptasaccharide with $\alpha1 \rightarrow 2$, $\alpha1 \rightarrow 3$ and $\alpha1 \rightarrow 6$ linkages and a tetrasaccharide consisting of $\alpha1 \rightarrow 3$ and $\alpha1 \rightarrow 2$ linkages, when bound to banana lectin (BanLec) has been evaluated by trNOE NMR methods and docking calculations. It was found that the molecular recognition event involves a conformational selection process with only one of the conformations present in the free state of the sugar being recognised at the lectin binding site.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley & Sons, Inc.
Keywords: Mannose oligosaccharides;NMR spectroscopy;Molecular dynamics;Banana lectin;Molecular recognition
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 03 Jun 2008
Last Modified: 19 Sep 2010 04:45
URI: http://eprints.iisc.ernet.in/id/eprint/14137

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