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In vivo treatment of Heymann's Nephritis using a cytotoxic protein-toxin conjugate

Misquith, Sandra and Surolia, Avadhesha (1995) In vivo treatment of Heymann's Nephritis using a cytotoxic protein-toxin conjugate. In: FEBS letters, 373 (2). pp. 151-154.

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Abstract

In this study we investigated the possibility of treating Heymann's Nephritis (HN) by destroying antibody producing cells by targetting a toxin, gelonin - conjugated to gp330, the renal brush border antigen. HN was induced in rats by immunizing them with purified gp330. The gelonin-gp330 conjugate was administered 12 days after the antigenic challenge. Serum was screened for circulating antibodies. Proteinurea was estimated. The gp330-gelonin conjugate-treated animals had a circulating antibody titre in the serum much lower than that of diseased (untreated) animals. Proteinurea seen in diseased animals was not observed in treated animals. This work suggests the possibility of using a toxin-antigen conjugate for immunomodulating antibody mediated autoimmune renal disease.

Item Type: Journal Article
Additional Information: The copyright belongs to Elsevier B.V.
Keywords: Heymann's Nephritis;Gelonin-gp330 conjugate;Cytotoxicity
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 25 Jun 2008
Last Modified: 19 Sep 2010 04:46
URI: http://eprints.iisc.ernet.in/id/eprint/14449

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