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Gonadotropin-releasing hormone in first trimester human placenta: isolation, partial characterization and in vitro biosynthesis

Mathialagan, N and Rao, Jagannadha A (1986) Gonadotropin-releasing hormone in first trimester human placenta: isolation, partial characterization and in vitro biosynthesis. In: Journal of Biosciences, 10 (4). pp. 429-441.

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Abstract

Using a specific RIA for gonadotropin-releasing hormone (I), the presence of I-like material in the 1st trimester human placenta was demonstrated. The material has been partially characterized using CMC chromatog., high pressure gel permeation chromatog., and reverse-phase C18 HPLC anal. Anal. for bioactivity revealed that placental I is much more active than synthetic I in in vitro rat pituitary LH release assay. In vitro biosynthetic studies using labeled precursors and immunoaffinity chromatog. indicated that 1st trimester human placenta synthesizes I-like material.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Gonadotropin;trimester human placenta;isolation;partial characterization;in vitro biosynthesis
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 25 Jun 2008
Last Modified: 27 Aug 2008 13:29
URI: http://eprints.iisc.ernet.in/id/eprint/14450

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